Gregory M Vercellotti Selected Research

Heme (Haem)

1/2022	Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence.
1/2021	Vasculo-toxic and pro-inflammatory action of unbound haemoglobin, haem and iron in transfusion-dependent patients with haemolytic anaemias.
1/2021	Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death.
1/2021	Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells.
1/2020	Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease.
1/2020	Antithrombotic effects of heme-degrading and heme-binding proteins.
1/2018	Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease.
1/2018	Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.
10/2017	Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate.
11/2016	Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.

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Gregory M Vercellotti Research Topics

Disease

33	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 05/2003
23	Inflammation (Inflammations) 01/2021 - 05/2003
16	Hemolysis 01/2022 - 08/2002
13	Hypoxia (Hypoxemia) 01/2022 - 07/2004
6	Neoplasms (Cancer) 01/2019 - 08/2008
5	Thrombosis (Thrombus) 01/2020 - 01/2006
5	Atherosclerosis 07/2010 - 08/2002
4	Sepsis (Septicemia) 01/2022 - 02/2013
4	Necrosis 01/2021 - 02/2013
4	Reperfusion Injury 11/2017 - 07/2003
3	Hemolytic Anemia 01/2021 - 07/2003
3	Pain (Aches) 01/2020 - 07/2018
3	Acute Kidney Injury (Acute Renal Failure) 01/2019 - 02/2013
3	Ischemia 01/2019 - 04/2010
2	Fever (Fevers) 01/2022 - 04/2020
2	Respiratory Insufficiency (Respiratory Failure) 01/2022 - 07/2018
2	Malaria 01/2021 - 01/2016
2	Hemorrhage 01/2019 - 12/2018
2	Prostatic Neoplasms (Prostate Cancer) 12/2013 - 08/2008
2	Vascular Diseases (Vascular Disease) 02/2013 - 09/2006
2	Atherosclerotic Plaque (Atheroma) 07/2010 - 03/2009
2	Vasculitis (Vasculitides) 11/2005 - 07/2003
1	Acute Pain 01/2022
1	Macrocytic Anemia 01/2022
1	Edema (Dropsy) 01/2022
1	Polyarteritis Nodosa (Periarteritis Nodosa) 01/2022
1	Thrombocytopenia (Thrombopenia) 01/2022
1	Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) 01/2022
1	Iron Overload 01/2021
1	Hereditary Spherocytosis 01/2021
1	Acute Chest Syndrome 01/2021
1	Cyanosis 04/2020
1	Exfoliative Dermatitis (Erythroderma) 04/2020
1	Erythema 04/2020
1	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 04/2020
1	Hypesthesia (Numbness) 04/2020
1	Hypotension (Low Blood Pressure) 04/2020
1	Job Syndrome (Hyper-IgE Syndrome) 04/2020
1	Intractable Pain 04/2020
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2020
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2020
1	Lung Injury 01/2020
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019
1	Cytokine Release Syndrome 01/2019

Drug/Important Bio-Agent (IBA)

22	Heme (Haem)IBA 01/2022 - 08/2002
14	Hemoglobins (Hemoglobin)IBA 11/2018 - 08/2002
9	Heme Oxygenase-1IBA 01/2020 - 03/2006
8	HemopexinIBA 01/2022 - 01/2013
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2003
7	IronIBA 01/2021 - 07/2003
6	HaptoglobinsIBA 01/2018 - 01/2013
5	Carbon MonoxideIBA 01/2018 - 10/2009
5	NF-kappa B (NF-kB)IBA 10/2017 - 07/2004
4	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2021 - 06/2005
4	CytokinesIBA 01/2020 - 07/2004
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2021 - 06/2005
3	Toll-Like Receptor 4IBA 01/2021 - 10/2017
3	LipopolysaccharidesIBA 01/2020 - 01/2014
3	GlobinsIBA 01/2019 - 04/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2017 - 08/2008
3	Hemin (Panhematin)FDA Link 11/2017 - 03/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2005 - 07/2003
2	Opioid Analgesics (Opioids)IBA 01/2022 - 07/2018
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2021 - 04/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 06/2015
2	Complement System Proteins (Complement)IBA 01/2021 - 01/2019
2	Fetal Hemoglobin (Hemoglobin F)IBA 01/2020 - 10/2017
2	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2020 - 01/2020
2	LigandsIBA 07/2018 - 08/2012
2	ethyl 6- (N- (2- chloro- 4- fluorophenyl)sulfamoyl)cyclohex- 1- ene- 1- carboxylateIBA 01/2018 - 01/2014
2	Hemeproteins (Heme Protein)IBA 01/2018 - 02/2013
2	Biomarkers (Surrogate Marker)IBA 11/2017 - 01/2006
2	Pharmaceutical PreparationsIBA 10/2017 - 09/2006
2	AntioxidantsIBA 10/2017 - 09/2016
2	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 06/2017 - 01/2013
2	LipidsIBA 07/2010 - 03/2009
1	ruxolitinibIBA 01/2022
1	Rituximab (Mabthera)FDA Link 01/2022
1	SteroidsIBA 01/2022
1	GlucocorticoidsIBA 01/2022
1	SelectinsIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	InflammasomesIBA 01/2021
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 04/2020
1	Staphylococcal enterotoxin FIBA 04/2020
1	Immunoglobulin E (IgE)IBA 04/2020
1	Thrombin FDA Link 01/2020
1	Glutamine (L-Glutamine)FDA Link 01/2020
1	crizanlizumabIBA 01/2020
1	Heme-Binding ProteinsIBA 01/2020
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	CateninsIBA 01/2019
1	Interleukin-2 (IL2)IBA 01/2019
1	heme oxygenase-2IBA 01/2019
1	von Willebrand FactorIBA 01/2019
1	Sirtuin 1IBA 01/2019
1	AutoantibodiesIBA 01/2019

Therapy/Procedure

15	Therapeutics 01/2021 - 05/2003
3	Cell Transplantation 01/2020 - 08/2009
1	Ligation 01/2020